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With moderate to severe ulcerative colitis (UC) or Crohn's disease (CD), your head may say one thing, but your gut says "not today". If your current treatment isn't working, ask your doctor about ENTYVIO. Individual results may vary.

With moderate to severe ulcerative colitis or Crohn's disease, your plans can change at any time.

Your head wants to do one thing, but your gut says "not today".

[SUPER] For moderate to severe ulcerative colitis or Crohn's disease.

[GRAPHIC] MADE FOR THE GI TRACT

GI-focused ENTYVIO is made for this.

[BULLETS]

ACTS SPECIFICALLY IN THE GI TRACT.
HELPS CONTROL INFLAMMATION IN THE GI TRACT.

[SUPER]
Blood vessel in the gastrointestinal (GI) tract.
Individual results may vary.
Available by prescription only.

ENTYVIO acts specifically in the GI tract to prevent an excess of white blood cells from entering and causing damaging inflammation.

[GRAPHIC] MADE FOR REMISSION

[SUPER] Individual results may vary.

ENTYVIO has helped many patients achieve long‑term relief and remission.

[GRAPHIC] MADE FOR YOU.

[SUPER] Individual results may vary.

It may help you, too.

[SUPER] ENTYVIO is given by IV infusion in the arm over 30 minutes.

Infusion and serious allergic reactions can happen during or after treatment.

ENTYVIO may increase risk of infection which can be serious.

Although unlikely, a risk of PML, a rare, serious, potentially fatal brain infection cannot be ruled out.

[SUPERS]
1.844.ENTYVIO
See our ad in Health magazine.

Tell your doctor if you have an infection, experience frequent infections, or have flu‑like symptoms or sores.

Liver problems can occur with ENTYVIO.

[GRAPHIC] ASK YOUR DOCTOR ABOUT ENTYVIO

[SUPER] Entyvio.com

If other treatments haven't worked well enough, ask your doctor about ENTYVIO.

[SUPERS]
MADE FOR THE GI TRACT
MADE FOR REMISSION
MADE FOR YOU

[SUPERS]
Find out if EntyvioConnect can help with the cost of treatment, whether you are insured or not.
Most patients pay between $0 and $5 per month for their medications*
Entyvio.com 1.844.ENTYVIO
*Must meet eligibility requirements.

If you're experiencing financial hardship during these trying times, Takeda may be able to help.

[SUPERS]
MADE FOR THE GI TRACT
MADE FOR REMISSION
MADE FOR YOU
If you're experiencing financial hardship during these trying times, Takeda may be able to help.
Entyvio.com 1.844.ENTYVIO

Important Safety Information about ENTYVIO^® (vedolizumab)

Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
ENTYVIO may cause serious side effects, including:
- Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
- ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
- People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
- Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO^® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

moderately to severely active ulcerative colitis
moderately to severely active Crohn’s disease

Important Safety Information about ENTYVIO^® (vedolizumab)

Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
ENTYVIO may cause serious side effects, including:
- Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
- ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
- People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
- Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO^® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

moderately to severely active ulcerative colitis
moderately to severely active Crohn’s disease

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